A Comparative Study Of Anand Bhairav Rasa And
Tribhuvana Kirti Rasa In The Management Of
Vata Kaphaja Jwara.
* Dr.virendra Baburao Pawar P.G. (Scholar) Department of Kayachikitsa.
drvirendra7007@gmail.com cell-09096743333
**prof. Dr. B.b. Kadlaskar M.D., Ph.D. (Kayachikitsa) H.O.D. & Professor.,
Department of Kaya-Chikitsa, B.V.D.U., College of Ayurved, Pune : 43. .
drkadlaskar@gmail.comcell- 09422330084
ABSTRACT
Background and Objective :
1) To compile reference regardingAnandbhairav rasa &Tribhuvanakirtirasa from classical
&contemporary literature.
2) To compile earlier references from classical and contemporary literature inAyurveda on
VataKaphajaJwara.
Method : Comparative single blind study. 40 patients were selected for the study and divided
into Two groups randomly.
Group A was given Anandbhairav rasa 250 mginternally1Tab twice a day.
Group Bwas given Tribhuvanakirti rasa 250 mg internally 1Tab twice a day.
Duration oftreatment : 7 days and Follow upeveryday.
This study was carriedout in BVDU College of Ayurved&Hospital attached to BharatiMedical
Foundation in Year 2013 and 2014.
Result : The clinical trial of AnandbhairavRasa and TribhuvankirtiRasa observed equally effective
in VatakaphajaJwara. Both drugs were equally effective on symptoms of VataKaphajaJwara
i.e. Staimityam, Parwanambhed, Gauravam, Shirograha, Pratishyaya,Kasa,
Swedapravartanam&Santapa (Temperature)in both groups .The Nidrawas reduced in group B
due to TribhuvankirtiRasa as compared to group A.In all symptoms the
P-Value isless than 0.05.
Statistical Analysis : Both groups were equally effective in the management of
VataKaphajaJwara.
Conclusion :
The evaluation of drugs in both groups were equally effective in the management of
VataKaphajaJwara.
The Jwaravyadhihas been studied from different samhitasin detail &also detail study of
VOL. THIRTY ONE- 01 ISSUE NO. 121 Jan.-Mar. 2015
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AnandbhairavRasa and Tribhuvankirti Rasa was carried out.
INTRODUCTION
Ayurveda is a science of life which protects health and preventsdiseases. Certain diseases
may not be life threatening but increasingly annoying and irritation to the individual in his
routine activity.If more over neglected they may lead to a series of complications later into
Acute Respiratory Diseases (ARD).
Ayurveda has described so manyvyadhis and theirchikitsa‘Jwara’ occupies first place among
the physical.
Jwara isincluded in Ashtamahagadmentioned by AcharyaCharaka.Jwaravyadhiis topamongst
all Vyadhismentioned in Ayurvedic classics.
Sometimes Jwarais present in body asLakshan(Symptom) or sometime it is a separate
Vyadhi (disease).
In Ayurvedictext Jwaraismentioned with its different types of Chikitsaaccording
toAvastha&types.Bruhatrai andLaghutraihas given so many formulation to treat the Jwara in
the form of Kashaya, Churna, Guti, Vatiand Rasa kalpa.Yogratnakar and Rasendrasarsangrah
has mentioned the Anandbhairav&TribhuvanaKirtiRasa in the treatment of Vata.KaphajaJwara.
AIM : To evaluate the Comparative efficacy of AnandbhairavRasa and TribhuvanaKirti Rasa on
VataKaphajaJwara.
OBJECTIVES :
1) To compile reference regarding Anandbhairav Rasa&TribhuvanakirtiRasa from classical&
contemporary literature.
2) To compile earlier references from classical and contemporary literature in Ayurveda on
VataKaphajaJwara .
MATERIALS AND METHODS :
DRUG REVIEW :-
1) ANANDBHAIRAV RASA :- RasendrasarSangraha - Jwarachikitsa 104-106.
Drugs :- Vatsanabha ,Hingula ,Shunthi ,Marich ,Pippali, Tankan,Javitri.
Method of Preparation :- Purified and driedVatsanabha , Hingula , Shunthi , Marich ,
Pippali, Tankan, Javitrichurnataken in equal quantity and triturated withJambiriNimbu
rasa and prepared Vatiof 250 mgtaken along with luke warm water.
2) TRIBHUVANA KIRTI RASA :- Yogratnakar–JwaraAdhikara.
Drugs :- Vatsanabha, Hingula, Shunthi, Marich, Pippali, Tankan, PippaliMoola .
Method of Preparation :- Purified and driedVatsanabha, Hingula, Shunthi, Marich,
VOL. THIRTY ONE- 01 ISSUE NO. 121 Jan.-Mar. 2015
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Pippali, Tankan, PippaliMoolataken in equal quantity inchurna form and 3 Bhavna of
Tulasipatra rasa,Adrakrasa and Dhattura rasa given.TribhuvanKirti rasa 250 mg taken
along with luke warm water.
PLAN OFRESEARCH :-
• For clinical trial special caseproformawas prepared.
• The patients were selected form B.V.D.U BharatiAyurvedHospital,Pune Kayachikitsa
Department IPD &OPD .
The rawmaterials were brought fromAyurvedicStoreDhankawadi, Pune.
These materials were identified and authenticated as per Ayurvedicpharmacopia norms
by the experts in the Botanical Department of University of Pune,Prepared and standardized
by analytical lab R.S.B.K.V Dept.. of B.V.D.U, College Of Ayurevd PUNE-43.
• Total 40 patients were enrolled and divided into 2 groups. Each group had 20 complete
sample.
Type ofstudy : Comparative single blind study.
DRUG ADMINISTRATOR SCHEDULE :
Particulars Group A Group B
No. of Patients 20 20
Medicine Given Anandbhairav Rasa TribhuvanaKirti Rasa
Dose250 mg. each tablet 250 mg. each tablet
Time Abhakta1 Tab Twice a Abhakta1 Tab Twice a
day day
Duration 7 Day 7 Day
AnupanLuke warm water Luke warm water
Route of Drug Administration Oral Oral
Follow upEveryday Everyday
ASSESSMENT CRITERIA :-
DIAGNOSTIC CRITERIA :- Symptoms of VatakaphajJwara as follows:
· Staimityam
· ParvanamBheda
· Nidra
· Gauravam
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· Shirograha
· Pratishyaya
· Kasa
· Swedapravartanam
· Santap (Temperature)
SUBJECTIVE CRITERIA :-
Full detailed history and physical examination of the patients were recorded into the
specially prepared case record proformafor VataKaphajaJwara.
Main criteria of the assessment was relief insymptoms and clinical end point.
The efficacy wascompared ,analyzed and assessed in Group A (Anandbhairav Rasa) and
Group B (TribhuvanaKirti Rasa).
Follow up was taken everyday.
OBJECTIVE CRITERIA :-
Axillary bodytemperature recorded by using thermometer .(Range of temperature 98.7oF
to 101oF.)
Temperature Gradation :-
Normal = 0
Mild (Normal to 99oF) = 1
Moderate (99.1oF to 100oF) = 2
Severe (100.1oF to 101oF) = 3
Gradation of symptoms:-
· Staimityam :- Absent : 0
(A feelingof dampness) Present : 1
· ParvanamBheda :- Absent : 0
(Pain in the small joints) Mild(Occasionally) : 1
Moderate (Intermediate pain) : 2
Severe (Continuous Pain) : 3
· Nidra :- Absent : 0
( Sleepiness) Mild (4-5 hrs/Interrupted) : 1
Moderate (2-3 hrs/) : 2
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Severe (1 to 2 hrs) : 3
· Gauravam :- Absent : 0
(Feeling of heaviness) Mild (Desire toactivity) : 1
Moderate (Fatigue after
Small activities) : 2
Severe (Do not want to do Activity) : 3
· Shirograha :- Absent : 0
(Headache) Mild (Occasionally) : 1
Moderate (Intermediate pain) : 2
Severe (Continuous Pain) : 3
· Pratishyaya :- Absent : 0
Coryza) Mild (Sneezing) : 1
Moderate (Sneezing withmild
discharge) : 2
Severe (Continues discharge) : 3
· Kasa :- Absent : 0
(Cough) Mild (1-3 Vega) : 1
Moderate (4-6 Vega) : 2
Severe (7-10 Vega) : 3
· Swedapravartanam :- Absent : 0
(NoSweating) Mild (Occasional Sweating) : 1
Moderate (Intermediate
Sweating) : 2
Severe (Continues Sweating) : 3
INCLUSION CRITERIA :-
· Sample size(40 patients ) were divided in 2 groups.
· Age group :- 19 to 55 years
· Patients were diagnosed on the basis of symptoms ofVataKaphajaJwara as per mentioned
in Ayurvedictext book.
· Range of temperature 98.7oF to 101oF.
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· Complaint of fever less than 7 days.
· Patients withboth gender were included.
EXCLUSIONCRITERIA :-
· Pregnancy
· History ofchronic fever.
· Patients suffering from Enteric fever were excluded.
· Malaria .
INVESTIGATION (PRE TRIAL)
· Haemogramwith ESR
· Platelet Count
· Urine :- Routineµscopic
· Widaltest
· PBS for M.P.
OBSERVATIONS
· STAIMITYAM :-
Staimityam Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 1 0 -3.419 .001 Significant
TribhuvanKirti Rasa 1 0 -3.755 .000 Significant
Comparative Analysis of improvement between Groups :
Median Mean Score Mann-Whitney P- Value
Improvement U statistic
AnandbhairavRasa 1 20.63 197.5 0.947
TribhuvanKirtiRasa 1 20.38
Distribution of improvements in Staimityam for AnandbhairavRasa&TribhuvanKirti Rasa were
not significantly different (P = 0.947). Therefore, Anandbhairav Rasa andTribhuvanKirti
Rasa wereequally effective in Staimityam.
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· PARWANAMBHED :-
Parwanambhed Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 1.5 0 -3.213 .001 Significant
TribhuvanKirti Rasa 2 0 -3.753 .000 Significant
Comparative Analysis of improvement between Groups :
Median Mean Score Mann-Whitney P- Value
Improvement U statistic
Anandbhairav Rasa 1.5 17.88
147.5 0.157
TribhuvanKirti Rasa 2 23.13
Distribution of improvements in Parwanambhedfor Anandbhairav Rasa&TribhuvanKirti Rasawere
not significantly different (P = 0.157). Therefore,Anandbhairav Rasa and TribhuvanKirti Rasa
were equally effective in Parwanambhed.
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· NIDRA :-
Nidra Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 1 0 -3.416 .001 Significant
TribhuvanKirti Rasa 2 0 -3.977 .000 Significant
Comparative Analysisof improvement between Groups :
Median Mean Score Mann-Whitney P- Value
Improvement U statistic
Anandbhairav Rasa 1 16.58
121.5 0.033
TribhuvanKirti Rasa 2 24.43
Distribution of improvements in Nidra for AnandbhairavRasa&TribhuvanKirtiRasa
wassignificantly different (P = 0.033).Therefore,AnandbhairavRasa and TribhuvanKirtiRasa
were not equally effective in Nidra.
· GAURAVAM :-
Gauravam Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 1 0 -3.153 .002 Significant
TribhuvanKirti Rasa 2 0 -3.602 .000 Significant
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Comparative Analysisof improvement between Groups :
Median Mean Score Mann-Whitney P- Value
Improvement U statistic
AnandbhairavRasa 1 17.65 143 0.127
TribhuvanKirtiRasa 2 23.35
Distribution of improvements in Gauravamfor Anandbhairav&TribhuvanKirtiwere not significantly
different (P = 0.127).Therefore,Anandbhairav andTribhuvanKirtiwere equally effective
in Gauravam.
· SHIROGRAHA :-
Shirograha Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 2 0 -3.314 .001 Significant
TribhuvanKirti Rasa 2 0 -3.354 .001 Significant
Comparative Analysis of improvement between Groups :
Median Mean Score Mann-Whitney P- Value
Improvement U statistic
AnandbhairavRasa 2 21.38 182.5 0.64
TribhuvanKirtiRasa 2 19.63
Distribution of improvements in Shirograha for Anandbhairav Rasa&TribhuvanKirti Rasa
were not significantly different (P = 0.64). Therefore,Anandbhairav Rasa and
TribhuvanKirti Rasa were equally effective in Shirograha.
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· PRATISHYAYA :-
Pratishyaya Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 2 0 -3.354 .001 Significant
TribhuvanKirti Rasa 0 0 -2.714 .007 Significant
Comparative Analysis of improvement between Groups:
Median Mean Score Mann-Whitney P- Value
mprovement U statistic
AnandbhairavRasa 2 23.05 149 0.174
TribhuvanKirtiRasa 0 17.95
Distribution of improvements in Pratishyaya for Anandbhairav&TribhuvanKirti were not
significantly different (P = 0.174). Therefore, Anandbhairav Rasa and TribhuvanKirtiRasa
were equally effective in Pratishyaya.
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· KASA :-
Kasa Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 2 0 -3.502 .000 Significant
TribhuvanKirti Rasa 2 0 -3.919 .000 Significant
Comparative Analysis of improvement between Groups :
Median Mean Score Mann-Whitney P- Value
mprovement U statistic
AnandbhairavRasa 2 19.25 175 0.512
TribhuvanKirtiRasa 2 21.75
Distribution of improvements in Kasa for Anandbhairav Rasa &TribhuvanKirti Rasa were
not significantly different (P = 0.512), Therefore, Anandbhairav Rasa and TribhuvanKirti
Rasa were equally effective in Kasa.
• SWEDAPRAVARTANAM :-
Swedapravartanm Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 3 0 -4.042 .000 Significant
TribhuvanKirti Rasa 3 0 -4.179 .000 Significant
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Comparative Analysis of improvement between Groups:
Median Mean Score Mann-Whitney P- Value
mprovement U statistic
AnandbhairavRasa 3 18.40 158 0.265
TribhuvanKirtiRasa 3 22.60
Distribution of improvements in Swedapravatanam for Anandbhairav&TribhuvanKirti were
not significantly different (P = 0.265), Therefore, Anandbhairav Rasa and TribhuvanKirti
Rasa were equally effective inSwedapravatanam.
· SANTAPA(TEMPERATURE) :-
Santapa Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 2 0 -3.985 .000 Significant
TribhuvanKirti Rasa 2 0 -3.895 .000 Significant
Comparative Analysis of improvement between Groups :
Median Mean Score Mann-Whitney P- Value
mprovement U statistic
AnandbhairavRasa 2 21.10 188 0.758
TribhuvanKirti Rasa 2 19.90
Distribution of improvements in Temperature for Anandbhairav&TribhuvanKirti were not
significantly different (P = 0.758). Therefore, Anandbhairav Rasa and TribhuvKirti
Rasa were equally effective in Santapa.
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DISCUSSION
Prakruti-The study shows that,
Out of 20 Patients in Group A, 1(5%) was of KaphaPradhan Pitta Prakruti, 3(15%) were
of KaphaPradhanVataPrakruti, 1(5%) was of Pitta PradhanKaphaPrakruti, 3(15%) were of
Pitta PradhanVataPrakruti, 2(10%) were of VataPradhanKaphaPrakruti and 10(50%) were
of VataPradhanPitta Prakruti.
Out of 20 Patients in Group B, 3(15%) were of KaphaPradhan Pitta Prakruti, 1(5%)
was of KaphaPradhanVataPrakruti, 0(0%) of Pitta PradhanKaphaPrakruti, 7(35%)
were of Pitta PradhanVataPrakruti, 0(0%) of VataPradhanKaphaPrakruti and 9(45%)
were of VataPradhan Pitta Prakruti.
Symptomatology :-
1. Staymityam (A feeling of dampness) :-
According to Wilcoxon Signed Rank ‘W’, Anandbhairav Rasa and Tribhuvankirti Rasa
both were statistically significant in Staymityamwhich were equally effective.
This study shows that Anandbhairav rasa and Tribhuvankirti rasa were effective in
VataKaphajaJwara. Staymityamwas reduced mostly due to common ingredients of
both drugs like Pippali, Marich, Dhattur, Shunthi having
propertiesUshna,TikshnaGunaand Vata-Kaphaghna.
2. Parwanambhed (Pain in the small joints) :-
According to Wilcoxon Signed Rank Statistic ‘W’, Anandbhairav Rasa and Tribhuvankirti
Rasa both were statistically significantin Parwanambhedwhich were equally effective.
Parwanambhed is a symptom ofVataKaphajaJwara due to vitiated VataDosha. It
reduces due to vataghna property of common ingredients of both drugs like Pippali,
Marich, Shunti, Tulsi .
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3. Nidra (Sleepiness) :-
According to Wilcoxon signed rank test ‘W’, TribhuvanKirti Rasawas more effective
than Anandbhairav Rasa and was statistically significant in Nidra.
It was effective due to Kaphaghna properties of Pippali, Shunti and Vatsanabha and
Vyavayi and Vikasiguna of Dhattur of TribhuvanKirti Rasa.
4. Gauravam(Feeling of heaviness) :-
According to Wilcoxon signed rank test ‘W’, Anandbhairav Rasa and Tribhuvankirti
Rasa were statistically significant in Gauravamwhich were equally effective.
This may be due to Ushna and Tikshnaguna of Pippali, Marich, Dhattur, Shunthi and
also vata- kaphaghna property of Tulsi and Tankan .
5. Pratishyaya (Coryza) :-
According to Wilcoxon signed rank test ‘W’ , Anandbhairav Rasa and Tribhuvankirti
Rasa were statistically significant in Pratishyayawhich were equally effective.
The reason for good result, may be due toKanthya, Ushna, Tridoshahar properties of
ingredients of both drugs likeDhatura, Vatsanabha, Shunti,Pippali, Adark, PippaliMoola
and Prabhav of Tulsi.
6. Shirograha (Headache) :-
According to Wilcoxon signed rank test ‘W’, Anandbhairav Rasa and TribhuvanKirti
Rasa were statistically significant in Shirograhawhich were equally effective.
Shirograha is a symptom due to vitiated Kapha and Vatadosha. Result may be due
toVataghna property of ingredients of both drugs like Shunthi, Pippali, Marich, Tulsi.
7. Kasa (Cough) :-
According to Wilcoxon signed rank test ‘W’, Anandbhairav Rasa and TribhuvankirtiRasa
were statistically significant in Kasa which were equally effective.
This may be due to Kasaghna property of Tulsi, Marich, Pippali,Javitri and JambirNimbu.
8. Swedapravartanam (No Sweating):-
According to Wilcoxon signed rank test ‘W’, Anandbhairav Rasa and Tribhuvankirti
Rasa were statistically significant in swedapravartanam which were equally effective.
The reason for good result , because of YogvahiGuna of Hingul, Tankan and
VyavayiGuna of Vatsanabha, Dhattura.
9. Santapa (Temperature) :
According to Wilcoxon signed rank test ‘W’, Anandbhairav Rasa and Tribhuvankirti
Rasa were statistically significant in Santapa (Temperature)which were equally
VOL. THIRTY ONE- 01 ISSUE NO. 121 Jan.-Mar. 2015
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effective. This may be due to Swedaajananproperty of Hingul, Tankan and VyavayiGuna
of Vatsanabha, Dhattura.
RESULT
1) The clinical trial of Anandbhairav Rasa and Tribhuvankirti Rasa observed equally
effective in VataKaphajaJwara.
2) The effect on symptoms i.e.Staimityam, Parwanambhed, Gauravam, Shirograha,
Pratishyaya, Kasa, Swedapravartanam&Santapa (Temperature) of both drugs was
approximately equal .
3) Comparatively Nidra symptom was reduced effectively in group B (Tribhuvankirti Rasa
as compared to group A (Anandbhairav Rasa).
4) In all symptoms the P-Value is less than 0.05.
CONCLUSION
The evaluation of drugs in both groups were equally effective in the management of
VataKaphajaJwara.
Jwaravyadhi has been studied from different samhitasin detail.
Detail study of Kalpas i.e. Anandbhairav Rasa and Tribhuvankirti Rasa was carried
out.
BIBLIOGRAPHY
Apte V. S. :‘The students’ Sanskrit Englishs Dictionary Published
byMotilalBanvaridasPublication, Delhi.
Arunadatta: SarvangsundariCommentaryon AshtangaHridaya,Krishnadas Academy,
Varanasi.
Baghel M.S. :Research In Ayurveda, MriduAyurvedic Publication,Jamnagar.
Bhavamishra: ‘BhavaPrakasha’ with VidyotiniHindi commentary
byBrahmashankarShastri,ChaukhambhaSanskrit series, Banaras (1956).
Bhavprakash: SastuSahityaVardhakaKaryalaya, Bombay. 3rd Edition (1982).
BhaishajyaRatnavali:Vidhyotinitika, ChaukhambhaSanskrit Series,Varanasi. (1962).
Chakradatta: VaidhyaprabhaHindiVyakhya, IndradevaTripathi,Chaukhambha Sanskrit
series, Varanasi.
Chakrapani: Ayurveda Dipikacommentary on CharakaSamhita, edited
byYadavjiTrikamjiAcharya, ChaukhambhaSanskrit Sansthana, Varanasi.
Charaka: CharakaSamhita with Vidhyotini Hindi commentary byKashinathShastri
andGorakhaNath, ChaukhambhaBhartiAcademy Varanasi.
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Charaka: CharakaSamhitawith English translation of ChakrapaniCommentary, by Bhagwan
Das,Chaukhambha Sanskrit Series, Varanasi.
Chopra R.N :Glossary of Indian Medicinal Plants, CSIR,NewDelhi.
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Davidson :Principles and practice of medicine; 16th edition. (1991)
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Physiology, & 7thedition,HarpercollinscollegePublishers.Laboratory diagnosis of Iron
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Professions Division. 15thedition
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ShrikanthaDatta with hindiVidhyotinicommentary by Shastri
S.ChaukhambhaSanskritaSansthana, Varanasi.
Medicinal Plants of India; Indian Council of MedicinalResearch; New Delhi. Vol. I, 1976,
MadhavaNidana– UttaradhaMadhukoshawithVidhyotiny, Hindi comm.by
SudarshanaShashtri (1954).
Michael Swash: Hutchison’s Clinical Methods, 20th edition.U.K.(1996)
P. V.Sharma DravyagunaVigyana, 15theditionChaukhambhaSurbharati Academy,
Varanasi.(1994):
P. V. Sharma :AyurvediyaVaigyanikaItihas.
SatoskarR. S. andBhandarakaraS. D:Pharmacology andPharmacotherapeutics , 12th
edition, PopularParakashana, Bombay.(1991)
Sharangdhara:SharangadharaGudharthaDipika Comm. edi-Parshuramashashtri, Varanasi
Tribhuvana Kirti Rasa In The Management Of
Vata Kaphaja Jwara.
* Dr.virendra Baburao Pawar P.G. (Scholar) Department of Kayachikitsa.
drvirendra7007@gmail.com cell-09096743333
**prof. Dr. B.b. Kadlaskar M.D., Ph.D. (Kayachikitsa) H.O.D. & Professor.,
Department of Kaya-Chikitsa, B.V.D.U., College of Ayurved, Pune : 43. .
drkadlaskar@gmail.comcell- 09422330084
ABSTRACT
Background and Objective :
1) To compile reference regardingAnandbhairav rasa &Tribhuvanakirtirasa from classical
&contemporary literature.
2) To compile earlier references from classical and contemporary literature inAyurveda on
VataKaphajaJwara.
Method : Comparative single blind study. 40 patients were selected for the study and divided
into Two groups randomly.
Group A was given Anandbhairav rasa 250 mginternally1Tab twice a day.
Group Bwas given Tribhuvanakirti rasa 250 mg internally 1Tab twice a day.
Duration oftreatment : 7 days and Follow upeveryday.
This study was carriedout in BVDU College of Ayurved&Hospital attached to BharatiMedical
Foundation in Year 2013 and 2014.
Result : The clinical trial of AnandbhairavRasa and TribhuvankirtiRasa observed equally effective
in VatakaphajaJwara. Both drugs were equally effective on symptoms of VataKaphajaJwara
i.e. Staimityam, Parwanambhed, Gauravam, Shirograha, Pratishyaya,Kasa,
Swedapravartanam&Santapa (Temperature)in both groups .The Nidrawas reduced in group B
due to TribhuvankirtiRasa as compared to group A.In all symptoms the
P-Value isless than 0.05.
Statistical Analysis : Both groups were equally effective in the management of
VataKaphajaJwara.
Conclusion :
The evaluation of drugs in both groups were equally effective in the management of
VataKaphajaJwara.
The Jwaravyadhihas been studied from different samhitasin detail &also detail study of
VOL. THIRTY ONE- 01 ISSUE NO. 121 Jan.-Mar. 2015
(19)
AnandbhairavRasa and Tribhuvankirti Rasa was carried out.
INTRODUCTION
Ayurveda is a science of life which protects health and preventsdiseases. Certain diseases
may not be life threatening but increasingly annoying and irritation to the individual in his
routine activity.If more over neglected they may lead to a series of complications later into
Acute Respiratory Diseases (ARD).
Ayurveda has described so manyvyadhis and theirchikitsa‘Jwara’ occupies first place among
the physical.
Jwara isincluded in Ashtamahagadmentioned by AcharyaCharaka.Jwaravyadhiis topamongst
all Vyadhismentioned in Ayurvedic classics.
Sometimes Jwarais present in body asLakshan(Symptom) or sometime it is a separate
Vyadhi (disease).
In Ayurvedictext Jwaraismentioned with its different types of Chikitsaaccording
toAvastha&types.Bruhatrai andLaghutraihas given so many formulation to treat the Jwara in
the form of Kashaya, Churna, Guti, Vatiand Rasa kalpa.Yogratnakar and Rasendrasarsangrah
has mentioned the Anandbhairav&TribhuvanaKirtiRasa in the treatment of Vata.KaphajaJwara.
AIM : To evaluate the Comparative efficacy of AnandbhairavRasa and TribhuvanaKirti Rasa on
VataKaphajaJwara.
OBJECTIVES :
1) To compile reference regarding Anandbhairav Rasa&TribhuvanakirtiRasa from classical&
contemporary literature.
2) To compile earlier references from classical and contemporary literature in Ayurveda on
VataKaphajaJwara .
MATERIALS AND METHODS :
DRUG REVIEW :-
1) ANANDBHAIRAV RASA :- RasendrasarSangraha - Jwarachikitsa 104-106.
Drugs :- Vatsanabha ,Hingula ,Shunthi ,Marich ,Pippali, Tankan,Javitri.
Method of Preparation :- Purified and driedVatsanabha , Hingula , Shunthi , Marich ,
Pippali, Tankan, Javitrichurnataken in equal quantity and triturated withJambiriNimbu
rasa and prepared Vatiof 250 mgtaken along with luke warm water.
2) TRIBHUVANA KIRTI RASA :- Yogratnakar–JwaraAdhikara.
Drugs :- Vatsanabha, Hingula, Shunthi, Marich, Pippali, Tankan, PippaliMoola .
Method of Preparation :- Purified and driedVatsanabha, Hingula, Shunthi, Marich,
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Pippali, Tankan, PippaliMoolataken in equal quantity inchurna form and 3 Bhavna of
Tulasipatra rasa,Adrakrasa and Dhattura rasa given.TribhuvanKirti rasa 250 mg taken
along with luke warm water.
PLAN OFRESEARCH :-
• For clinical trial special caseproformawas prepared.
• The patients were selected form B.V.D.U BharatiAyurvedHospital,Pune Kayachikitsa
Department IPD &OPD .
The rawmaterials were brought fromAyurvedicStoreDhankawadi, Pune.
These materials were identified and authenticated as per Ayurvedicpharmacopia norms
by the experts in the Botanical Department of University of Pune,Prepared and standardized
by analytical lab R.S.B.K.V Dept.. of B.V.D.U, College Of Ayurevd PUNE-43.
• Total 40 patients were enrolled and divided into 2 groups. Each group had 20 complete
sample.
Type ofstudy : Comparative single blind study.
DRUG ADMINISTRATOR SCHEDULE :
Particulars Group A Group B
No. of Patients 20 20
Medicine Given Anandbhairav Rasa TribhuvanaKirti Rasa
Dose250 mg. each tablet 250 mg. each tablet
Time Abhakta1 Tab Twice a Abhakta1 Tab Twice a
day day
Duration 7 Day 7 Day
AnupanLuke warm water Luke warm water
Route of Drug Administration Oral Oral
Follow upEveryday Everyday
ASSESSMENT CRITERIA :-
DIAGNOSTIC CRITERIA :- Symptoms of VatakaphajJwara as follows:
· Staimityam
· ParvanamBheda
· Nidra
· Gauravam
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· Shirograha
· Pratishyaya
· Kasa
· Swedapravartanam
· Santap (Temperature)
SUBJECTIVE CRITERIA :-
Full detailed history and physical examination of the patients were recorded into the
specially prepared case record proformafor VataKaphajaJwara.
Main criteria of the assessment was relief insymptoms and clinical end point.
The efficacy wascompared ,analyzed and assessed in Group A (Anandbhairav Rasa) and
Group B (TribhuvanaKirti Rasa).
Follow up was taken everyday.
OBJECTIVE CRITERIA :-
Axillary bodytemperature recorded by using thermometer .(Range of temperature 98.7oF
to 101oF.)
Temperature Gradation :-
Normal = 0
Mild (Normal to 99oF) = 1
Moderate (99.1oF to 100oF) = 2
Severe (100.1oF to 101oF) = 3
Gradation of symptoms:-
· Staimityam :- Absent : 0
(A feelingof dampness) Present : 1
· ParvanamBheda :- Absent : 0
(Pain in the small joints) Mild(Occasionally) : 1
Moderate (Intermediate pain) : 2
Severe (Continuous Pain) : 3
· Nidra :- Absent : 0
( Sleepiness) Mild (4-5 hrs/Interrupted) : 1
Moderate (2-3 hrs/) : 2
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Severe (1 to 2 hrs) : 3
· Gauravam :- Absent : 0
(Feeling of heaviness) Mild (Desire toactivity) : 1
Moderate (Fatigue after
Small activities) : 2
Severe (Do not want to do Activity) : 3
· Shirograha :- Absent : 0
(Headache) Mild (Occasionally) : 1
Moderate (Intermediate pain) : 2
Severe (Continuous Pain) : 3
· Pratishyaya :- Absent : 0
Coryza) Mild (Sneezing) : 1
Moderate (Sneezing withmild
discharge) : 2
Severe (Continues discharge) : 3
· Kasa :- Absent : 0
(Cough) Mild (1-3 Vega) : 1
Moderate (4-6 Vega) : 2
Severe (7-10 Vega) : 3
· Swedapravartanam :- Absent : 0
(NoSweating) Mild (Occasional Sweating) : 1
Moderate (Intermediate
Sweating) : 2
Severe (Continues Sweating) : 3
INCLUSION CRITERIA :-
· Sample size(40 patients ) were divided in 2 groups.
· Age group :- 19 to 55 years
· Patients were diagnosed on the basis of symptoms ofVataKaphajaJwara as per mentioned
in Ayurvedictext book.
· Range of temperature 98.7oF to 101oF.
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· Complaint of fever less than 7 days.
· Patients withboth gender were included.
EXCLUSIONCRITERIA :-
· Pregnancy
· History ofchronic fever.
· Patients suffering from Enteric fever were excluded.
· Malaria .
INVESTIGATION (PRE TRIAL)
· Haemogramwith ESR
· Platelet Count
· Urine :- Routineµscopic
· Widaltest
· PBS for M.P.
OBSERVATIONS
· STAIMITYAM :-
Staimityam Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 1 0 -3.419 .001 Significant
TribhuvanKirti Rasa 1 0 -3.755 .000 Significant
Comparative Analysis of improvement between Groups :
Median Mean Score Mann-Whitney P- Value
Improvement U statistic
AnandbhairavRasa 1 20.63 197.5 0.947
TribhuvanKirtiRasa 1 20.38
Distribution of improvements in Staimityam for AnandbhairavRasa&TribhuvanKirti Rasa were
not significantly different (P = 0.947). Therefore, Anandbhairav Rasa andTribhuvanKirti
Rasa wereequally effective in Staimityam.
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· PARWANAMBHED :-
Parwanambhed Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 1.5 0 -3.213 .001 Significant
TribhuvanKirti Rasa 2 0 -3.753 .000 Significant
Comparative Analysis of improvement between Groups :
Median Mean Score Mann-Whitney P- Value
Improvement U statistic
Anandbhairav Rasa 1.5 17.88
147.5 0.157
TribhuvanKirti Rasa 2 23.13
Distribution of improvements in Parwanambhedfor Anandbhairav Rasa&TribhuvanKirti Rasawere
not significantly different (P = 0.157). Therefore,Anandbhairav Rasa and TribhuvanKirti Rasa
were equally effective in Parwanambhed.
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· NIDRA :-
Nidra Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 1 0 -3.416 .001 Significant
TribhuvanKirti Rasa 2 0 -3.977 .000 Significant
Comparative Analysisof improvement between Groups :
Median Mean Score Mann-Whitney P- Value
Improvement U statistic
Anandbhairav Rasa 1 16.58
121.5 0.033
TribhuvanKirti Rasa 2 24.43
Distribution of improvements in Nidra for AnandbhairavRasa&TribhuvanKirtiRasa
wassignificantly different (P = 0.033).Therefore,AnandbhairavRasa and TribhuvanKirtiRasa
were not equally effective in Nidra.
· GAURAVAM :-
Gauravam Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 1 0 -3.153 .002 Significant
TribhuvanKirti Rasa 2 0 -3.602 .000 Significant
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Comparative Analysisof improvement between Groups :
Median Mean Score Mann-Whitney P- Value
Improvement U statistic
AnandbhairavRasa 1 17.65 143 0.127
TribhuvanKirtiRasa 2 23.35
Distribution of improvements in Gauravamfor Anandbhairav&TribhuvanKirtiwere not significantly
different (P = 0.127).Therefore,Anandbhairav andTribhuvanKirtiwere equally effective
in Gauravam.
· SHIROGRAHA :-
Shirograha Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 2 0 -3.314 .001 Significant
TribhuvanKirti Rasa 2 0 -3.354 .001 Significant
Comparative Analysis of improvement between Groups :
Median Mean Score Mann-Whitney P- Value
Improvement U statistic
AnandbhairavRasa 2 21.38 182.5 0.64
TribhuvanKirtiRasa 2 19.63
Distribution of improvements in Shirograha for Anandbhairav Rasa&TribhuvanKirti Rasa
were not significantly different (P = 0.64). Therefore,Anandbhairav Rasa and
TribhuvanKirti Rasa were equally effective in Shirograha.
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· PRATISHYAYA :-
Pratishyaya Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 2 0 -3.354 .001 Significant
TribhuvanKirti Rasa 0 0 -2.714 .007 Significant
Comparative Analysis of improvement between Groups:
Median Mean Score Mann-Whitney P- Value
mprovement U statistic
AnandbhairavRasa 2 23.05 149 0.174
TribhuvanKirtiRasa 0 17.95
Distribution of improvements in Pratishyaya for Anandbhairav&TribhuvanKirti were not
significantly different (P = 0.174). Therefore, Anandbhairav Rasa and TribhuvanKirtiRasa
were equally effective in Pratishyaya.
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· KASA :-
Kasa Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 2 0 -3.502 .000 Significant
TribhuvanKirti Rasa 2 0 -3.919 .000 Significant
Comparative Analysis of improvement between Groups :
Median Mean Score Mann-Whitney P- Value
mprovement U statistic
AnandbhairavRasa 2 19.25 175 0.512
TribhuvanKirtiRasa 2 21.75
Distribution of improvements in Kasa for Anandbhairav Rasa &TribhuvanKirti Rasa were
not significantly different (P = 0.512), Therefore, Anandbhairav Rasa and TribhuvanKirti
Rasa were equally effective in Kasa.
• SWEDAPRAVARTANAM :-
Swedapravartanm Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 3 0 -4.042 .000 Significant
TribhuvanKirti Rasa 3 0 -4.179 .000 Significant
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Comparative Analysis of improvement between Groups:
Median Mean Score Mann-Whitney P- Value
mprovement U statistic
AnandbhairavRasa 3 18.40 158 0.265
TribhuvanKirtiRasa 3 22.60
Distribution of improvements in Swedapravatanam for Anandbhairav&TribhuvanKirti were
not significantly different (P = 0.265), Therefore, Anandbhairav Rasa and TribhuvanKirti
Rasa were equally effective inSwedapravatanam.
· SANTAPA(TEMPERATURE) :-
Santapa Median Wilcoxon P-Value Result
Before After Signed Rank
Treatment Treatment Statistic ‘W’
Anandbhairav Rasa 2 0 -3.985 .000 Significant
TribhuvanKirti Rasa 2 0 -3.895 .000 Significant
Comparative Analysis of improvement between Groups :
Median Mean Score Mann-Whitney P- Value
mprovement U statistic
AnandbhairavRasa 2 21.10 188 0.758
TribhuvanKirti Rasa 2 19.90
Distribution of improvements in Temperature for Anandbhairav&TribhuvanKirti were not
significantly different (P = 0.758). Therefore, Anandbhairav Rasa and TribhuvKirti
Rasa were equally effective in Santapa.
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DISCUSSION
Prakruti-The study shows that,
Out of 20 Patients in Group A, 1(5%) was of KaphaPradhan Pitta Prakruti, 3(15%) were
of KaphaPradhanVataPrakruti, 1(5%) was of Pitta PradhanKaphaPrakruti, 3(15%) were of
Pitta PradhanVataPrakruti, 2(10%) were of VataPradhanKaphaPrakruti and 10(50%) were
of VataPradhanPitta Prakruti.
Out of 20 Patients in Group B, 3(15%) were of KaphaPradhan Pitta Prakruti, 1(5%)
was of KaphaPradhanVataPrakruti, 0(0%) of Pitta PradhanKaphaPrakruti, 7(35%)
were of Pitta PradhanVataPrakruti, 0(0%) of VataPradhanKaphaPrakruti and 9(45%)
were of VataPradhan Pitta Prakruti.
Symptomatology :-
1. Staymityam (A feeling of dampness) :-
According to Wilcoxon Signed Rank ‘W’, Anandbhairav Rasa and Tribhuvankirti Rasa
both were statistically significant in Staymityamwhich were equally effective.
This study shows that Anandbhairav rasa and Tribhuvankirti rasa were effective in
VataKaphajaJwara. Staymityamwas reduced mostly due to common ingredients of
both drugs like Pippali, Marich, Dhattur, Shunthi having
propertiesUshna,TikshnaGunaand Vata-Kaphaghna.
2. Parwanambhed (Pain in the small joints) :-
According to Wilcoxon Signed Rank Statistic ‘W’, Anandbhairav Rasa and Tribhuvankirti
Rasa both were statistically significantin Parwanambhedwhich were equally effective.
Parwanambhed is a symptom ofVataKaphajaJwara due to vitiated VataDosha. It
reduces due to vataghna property of common ingredients of both drugs like Pippali,
Marich, Shunti, Tulsi .
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3. Nidra (Sleepiness) :-
According to Wilcoxon signed rank test ‘W’, TribhuvanKirti Rasawas more effective
than Anandbhairav Rasa and was statistically significant in Nidra.
It was effective due to Kaphaghna properties of Pippali, Shunti and Vatsanabha and
Vyavayi and Vikasiguna of Dhattur of TribhuvanKirti Rasa.
4. Gauravam(Feeling of heaviness) :-
According to Wilcoxon signed rank test ‘W’, Anandbhairav Rasa and Tribhuvankirti
Rasa were statistically significant in Gauravamwhich were equally effective.
This may be due to Ushna and Tikshnaguna of Pippali, Marich, Dhattur, Shunthi and
also vata- kaphaghna property of Tulsi and Tankan .
5. Pratishyaya (Coryza) :-
According to Wilcoxon signed rank test ‘W’ , Anandbhairav Rasa and Tribhuvankirti
Rasa were statistically significant in Pratishyayawhich were equally effective.
The reason for good result, may be due toKanthya, Ushna, Tridoshahar properties of
ingredients of both drugs likeDhatura, Vatsanabha, Shunti,Pippali, Adark, PippaliMoola
and Prabhav of Tulsi.
6. Shirograha (Headache) :-
According to Wilcoxon signed rank test ‘W’, Anandbhairav Rasa and TribhuvanKirti
Rasa were statistically significant in Shirograhawhich were equally effective.
Shirograha is a symptom due to vitiated Kapha and Vatadosha. Result may be due
toVataghna property of ingredients of both drugs like Shunthi, Pippali, Marich, Tulsi.
7. Kasa (Cough) :-
According to Wilcoxon signed rank test ‘W’, Anandbhairav Rasa and TribhuvankirtiRasa
were statistically significant in Kasa which were equally effective.
This may be due to Kasaghna property of Tulsi, Marich, Pippali,Javitri and JambirNimbu.
8. Swedapravartanam (No Sweating):-
According to Wilcoxon signed rank test ‘W’, Anandbhairav Rasa and Tribhuvankirti
Rasa were statistically significant in swedapravartanam which were equally effective.
The reason for good result , because of YogvahiGuna of Hingul, Tankan and
VyavayiGuna of Vatsanabha, Dhattura.
9. Santapa (Temperature) :
According to Wilcoxon signed rank test ‘W’, Anandbhairav Rasa and Tribhuvankirti
Rasa were statistically significant in Santapa (Temperature)which were equally
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effective. This may be due to Swedaajananproperty of Hingul, Tankan and VyavayiGuna
of Vatsanabha, Dhattura.
RESULT
1) The clinical trial of Anandbhairav Rasa and Tribhuvankirti Rasa observed equally
effective in VataKaphajaJwara.
2) The effect on symptoms i.e.Staimityam, Parwanambhed, Gauravam, Shirograha,
Pratishyaya, Kasa, Swedapravartanam&Santapa (Temperature) of both drugs was
approximately equal .
3) Comparatively Nidra symptom was reduced effectively in group B (Tribhuvankirti Rasa
as compared to group A (Anandbhairav Rasa).
4) In all symptoms the P-Value is less than 0.05.
CONCLUSION
The evaluation of drugs in both groups were equally effective in the management of
VataKaphajaJwara.
Jwaravyadhi has been studied from different samhitasin detail.
Detail study of Kalpas i.e. Anandbhairav Rasa and Tribhuvankirti Rasa was carried
out.
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